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Provo — Tute Genomics has announced that its genome annotation and discovery platform will support Brigham Young University’s efforts to advance Alzheimer’s disease genetics research. This collaboration involves analysis and interpretation of next-generation sequencing data from more than 1,000 exomes and genomes to identify new genetic variants associated with the disease.
“Collaboration is the key to discovering novel variants in genomics research, and Tute Genomics is honored to play a role in supporting this important work,” said Kai Wang, president of Tute Genomics.
John “Keoni” Kauwe is leading a group of scientists from the BYU College of Life Sciences that is leveraging Tute Genomics in a large-scale effort to better understand the genetic basis of Alzheimer’s disease. The causes of this brain disease are still not fully understood and traditional treatments have so far proven unsuccessful. Kauwe’s group is looking to use Tute Genomics’ biomarker discovery platform to identify novel targets that may be used for therapeutic interventions.
“We have been extremely impressed with the Tute platform thus far, and we already have a number of research findings we are evaluating," Kauwe said.
The Alzheimer’s Genetic Analysis Group is a collaborative effort led by John Hardy at University College London. Other principal investigators in this group include Kauwe from BYU, Alison Goate and Carlos Cruchaga at the Washington University School of Medicine and Andrew Singleton at the National Institutes of Health. Late last year this group discovered a novel genetic variant that doubles a person’s risk of developing the disease later in life. The study included families that had several members with Alzheimer’s. The scientists sequenced and compared genes of those individuals affected by the disease and those who were not. They were then able to identify variations in a gene that appeared in affected family members.
Another of their recent studies has helped lift the veil on some of the mystery surrounding the causes of Alzheimer’s. The research team analyzed data from more than 25,000 people and reported that a rare genetic mutation in TREM2, a gene with function in the immune and inflammatory response, increases the risk of Alzheimer’s disease.